Combined transplantation of pancreatic islets and hepatocytes in the treatment of diabetic rats
- VernacularTitle:胎肝胰岛细胞联合移植治疗糖尿病大鼠
- Author:
Xiaorong LI
;
Daojing CHEN
;
Xinsheng LU
;
Min HAN
- Publication Type:Journal Article
- Keywords:
DIABETES MELLITUS/ther;
TRANSPLANTATION,HEPATOCYTES;
ISLETS OF LANGERHANS TRANSPLANTATION;
DISEASE MODELS,ANIMAL
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of combined transplantation of pancreatic islets and hepatocytes on the treatment of diabetic rats and the possibility on hepatocytes inducing islet allograft tolerance. Methods Forty diabetic SD rats were randomly divided into 4 groups: normal control group,diabetic control group, pancreatic islet grafted group,and hepatocyte and pancreatic islet transplanted group. The pancreatic islets of fetal SD rats were implanted into the gastric subserosa of recipients. The alteration of diabetes and immune status were observed. Results There were 58.8% (20/34) diabetic rats cured after pancreatic islets transplantation. The survival time in the combined grafted group was longer than that in the pancreatic islet grafted group ( P
