Relationship between absence of expression of DPC4/SMAD4 gene and pathogenesis of pancreatic carcinoma
- VernacularTitle:抑癌基因DPC4/SMAD4的缺失表达与胰腺肿瘤的关系
- Author:
Zhaohui TANG
;
Shengquan ZOU
- Publication Type:Journal Article
- Keywords:
PANCREATIC NEOPLASMS/genet;
GENES,SUPPRESSOR,TUMOR;
GENE EXPRESSION;
REVIEW LITERATURE
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To review the relationship between absence of expression of DPC4/SMAD4 gene and pathogenesis of pancreatic carcinoma(PC). Methods A summerized paper was made on the review of relative literatures. Results and Conclusions A new gene DPC4 (located on chromosome 18q21.1 region) has been identified as a candidate tumor suppression gene. SMAD4 belongs to the evolutionarily conserved family of SMADs proteins that are crucial intracellular mediators of signals from the transforming growth factor ?(TGF-?). In TGF-? super family signal pathways, SMAD4 plays a pivotal role .There is a close relationship between absence of expression of DPC4 gene and pathogenesis of pancreatic carcinoma.
