The relaxation of rabbit femoral artery induced by cAMP is partly dependent on nitric oxide
- VernacularTitle:cAMP产生的兔股动脉舒张部分由NO介导
- Author:
Ling GAO
;
Biao XU
;
Ferr ALBERT
- Publication Type:Journal Article
- Keywords:
Adenosine cyclic monophosphate;
Nitric oxide;
Femoral artery;
Endothelium
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To determine whether vasorelaxation induced by cAMP is dependent on eNOS activation.METHODS: A constant perfusion model of rabbit femoral artery was used to observe the changes of perfusion pressure before and after intra-arterial infusing different concentrations of dbcAMP(a membrane-permeable cAMP analogue) or forskolin(a direct stimulator of adenyl cyclase) and the effects of NOS inhibitor L-NAME on their actions.RESULTS: Both dbcAMP and forskolin induced concentration-dependent relaxation of rabbit femoral artery bed and NOS inhibitor L-NAME partly inhibited this vasorelaxation.CONCLUSION: Vasorelaxation induced by cAMP is mediated partly through eNOS activation.
