Effects of glucocorticoids on the glucocorticoid receptor ? and ? mRNA expression
- VernacularTitle:糖皮质激素对糖皮质激素受体?和?mRNA表达的调节作用
- Author:
Yujian LIU
;
Liangnian SONG
;
Jian LU
- Publication Type:Journal Article
- Keywords:
Glucocorticoids;
RNA, messenger;
Osteosarcoma;
Ovarian neoplasms
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To clarify the effects of glucocorticoids on the messenger RNA expression of glucocorticoid receptor (GR? and GR?). METHODS: messenger RNA of GR ? and GR? were determined by quantitive RT-PCR. RESULTS: Besides GR? mRNA, GR? mRNA is also expressed in human osteosarcoma cell line HOS-8603, human ovarian carcinoma cell line 3AO and human peripheral white blood cells. After administration of dexamethasone, both GR? mRNA and GR? mRNA were down-regulated in a time-dependent and dose-dependent manner. CONCLUSION: GR? expresses in various kinds of human tissue cells. The expression of GR? is regulated by glucocorticoids.
