TGF-? intracellular signal transduction and Smads protein
- VernacularTitle:转化生长因子?胞内信号转导与Smads蛋白
- Author:
Junfang ZHAO
;
Cheng LIU
;
Chenghai LIU
- Publication Type:Journal Article
- Keywords:
Transforming growth factor beta;
Signal transduction;
Smads protein
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Transforming growth factor-? (TGF-?) is a multifunctional peptide growth factor with a wide range of effects. TGF-? signals are conveyed through cell-surface serine/threonine kinase receptors to the downstream cytoplasmic mediators, known as Smads proteins. Receptor-regulated Smads become phosphorylated by activated type Ⅰ receptors and form heteromeric complexes with a common Smad-Smad4, which translocates into the nucleus to regulate gene transcription. Inhibitory Smads inhibit the activation of receptor-regulated Smads. There are positive, negative and feedback regulations in the Smads mediated TGF-? signaling pathway.
