Correlation between quantified electroencephalograph and end-tidal desflurane concentration during low-flow desflurane anesthesia
- VernacularTitle:低流量地氟醚吸入麻醉时呼气末浓度和理论血药浓度与数量化脑电图的相关性
- Author:
Biao ZHU
;
Min LI
;
Zhanggang XUE
;
Al ET
- Publication Type:Journal Article
- Keywords:
Anesthesia, inhalation;
Electroencephalogram;
Desflurane
- From:
Chinese Journal of Anesthesiology
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the quantified electroencephalograph (EEG) and end-tidal desflurane concentration and characteristics of desflurane absorption during low-flow desflurane anesthesia. Methods Fifteen ASA I - Ⅱ patients with a mean age of (51.6?11.9)yr, weighing (59.6?7.9)kg scheduled for operation performed under combined general and epidural anesthesia were studied. The patients were premedicated with phenobarbital 0.1g and atropine 0.5mg.Epidural catheter was placed and a test dose of 1.0% lidocaine and 0.2% tetracaine was given before induction of general anesthesia. General anesthesia was induced with fentanyl 2-3?g?kg-1, thiopental 4-7mg?kg-1 and succinyl choline 1.5-2.0 mg?kg-1 and maintained with desflurane, intermittent iv boluses of vecuronium and epidural anesthesia. Desflurane anesthesia was started with high-flow for 15min followed by low flow. During high-flow wash-in, FGF was 4L/min, VT was set at 8-10ml?kg-1, PETCO2 was maintained at 4.2-4.6kPa(32-35mm Hg) and desflurane vaporizer was set at 5% .During low-flow FGF 0.5L/min. End-tidal desflurane concentration(Fa) and inspired desflurane concentration (Fi), BIS, SEF90 were recorded at 3,9, 12 and 15min during high-flow wash-in and at 3%, 4.5% and 6% Fa during low-flow. Each Fa was maintained for at least 15min.Results Before induction of anesthesia BIS was 86.0?8.3, SEF95 20.2? 1.8 and SEF90 18.0 ? 2.3 and at the end of 15min high-flow induction they were reduced to 50.4 ? 5.4 (BIS),13.0?1.6(SEF95) and 12.2?1.1(SEF90).The differences were statistically different (P
