The effect of propofol on isolated human bronchial smooth muscle
- VernacularTitle:异丙酚对离体人支气管平滑肌的作用
- Author:
Yaping WANG
;
Yetian CHANG
;
Donglin YANG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Propofol;
Bronchi;
Muscle, smooth
- From:
Chinese Journal of Anesthesiology
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Propofol is now the most commonly used intravenous anesthetic. It has vasodilating effect. The purpose of this study is to determine its effect on bronchial smooth muscle. Methods Strips of bronchus (40x2cm2) were taken from the lung resected during lung surgery and suspended a bath filled with K-H solution. One end of the bronchus strip was fixed to the bottom of the bath and the other was attached to a tension transducer through a piece of wire. Bronchoconstriction was induced with acetylcholine added in K-H solution (3?g?ml-1). When peak bronchoconstriction was reached, propofol in fat emulsion was added culmulatively to the bath (1,2,5, 10,20?g?ml-1). The effect of fat emulsion was also examined as control. Results Propofol at concentrations of 1, 2, 5, 10 and 20(?g?ml-1 caused a significant decrease in the acetylcholine-induced bronchoconstriction in a dose dependent manner. Conclusions Propofol at clinically relevant concentrations significantly attenuates acetylcholine-induced bronchoconstriction in human.
