Effects of droperidol on sodium currents in isolated rat dorsal root ganglion neurons
- VernacularTitle:氟哌利多对大鼠背根神经节细胞钠电流的影响
- Author:
Meng CHEN
;
Xinliang ZHUANG
;
Guohui XU
- Publication Type:Journal Article
- Keywords:
Droperidol;
Ganglia, spinal;
Sodium channels
- From:
Chinese Journal of Anesthesiology
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of droperidol on the Na+ currents in rat dorsal root ganglion neurons.Methods The rat dorsal root ganglion neurons were enzymatically dissociated. Whole-cell patch-clamp technique was applied to record Na+ current. Results 3-300?mol?L-1 Droperidol inhibited the sodium currents by 14.12%-78.46% (P0.05, n =7).Conclusions Droperidol inhibits Na+ currents in rat dorsal root ganglion neurons in a concentration- and voltage-dependent manner. The results suggest that the concentration of epidural droperidol clinically applied during epidural patient control analgesia may enhance the analgesic effects.
