Expression of vascular endothelial growth factor in esophagus after pericardial devascularization in portal hypertensive rats
- VernacularTitle:血管内皮生长因子在门静脉高压症鼠断流术后食管中的表达
- Author:
Yang XU
;
Zhiping CHEN
;
Zhiyong WU
- Publication Type:Journal Article
- Keywords:
Hypertension,portal;
Endothelial growth factor
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of vascular endothelial growth factor (VEGF) expression on varicose recurrence in esophagus after devascularization in portal hypertensive rats. Methods Murine pre-hepatic portal hypertension (PHPH) was induced by partial portal vein stenosis. 3 weeks after the establishment of the PHPH, all rats including sham operation group (SO) underwent devascularization. Esophagus was sampled at the time of 1, 3, 5, 7, 14, 30, 90 days after devascularization respectively. The expression of VEGF and factor Ⅷ related antigen (FⅧAg) was detected by immunohistochemistry,and the microvessel density (MVD) was counted under FⅧAg staining. ResultsCompared to the SO rats, the MVD of esophagus in PHPH rats increased significantly before devascularization(P0.05). At the third month after devascularization, the MVD of PHPH rats was higher than that of SO rats. In SO rats, MVD increased after devascularization, reaching the peak on the third day and then levelling off.The expression of VEGF before devascularization in PHPH rats was significantly higher than in SO rats, and VEGF experssion was on the pinnacle in two groups after devascularization, but the expression time of PHPH rats was significantly longer than SO rats(P
