The influence of fibrin glue and growth hormone on the healing of small bowel anastomosis in a murine peritonitis model
- VernacularTitle:纤维蛋白胶和生长激素促进腹腔感染条件下大鼠肠吻合口愈合的研究
- Author:
Tao JIANG
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Peritonitis;
Anastomosis,surgical;
Fibrin tissue adhesive
- From:
Chinese Journal of General Surgery
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of fibrin glue(FG) and growth hormone(GH) on the anastomosis of the small bowel at peritonitis. MethodsResection and anastomoses of the small bowel at peritonitis was performed in rats. In group N:normal control;in group A:a standard anastomosis was constructed with 12 silk sutures;in group B:an incomplete anastomosis was constructed with only 4 silk sutures;in group C: incomplete anastomosis+FG;in group D: incomplete anastomosis+GH;in group E: incomplete anastomosis+FG+GH.On days 1,3 and 5,ten rats in each group were sacrificed.The healing of anastomosis were evaluated,the anastomotic bursting pressure and hydroxyproline concentration were measured. Results In group A the bursting pressure was low from day 1 to day 3(18?10?mm?Hg and 36?11?mm?Hg each).The percent of false-healing was 30%,significantly higher than group N.The bursting pressure in group C was significantly higher than in group A(32?7?mm?Hg and 65?9?mm?Hg each),the healing of the anastomosis was significantly improved,the percent of false-healing was 11.7%.Hydroxyproline concentration of each group showed no differences. Conclusion Fibrin glue helps the healing of the anastomosis of the small bowel at peritonitis in rats,and can protect it from complications. The addition of GH does not improve healing.
