Treatment of Hypoxic Pulmonary Hypertension With L-arginine
- VernacularTitle:L-精氨酸治疗缺氧性肺动脉高压
- Author:
Junbao DU
;
Jianguang QI
;
Zhanmin MA
- Publication Type:Journal Article
- Keywords:
L-arginine;
pulmonary artery;
endothelin-I;
hypoxia
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the mechanism by which L-arginine regulates hypoxic pulmonary vascular structural remodeling.METHODS:Eighteen Wistar rats were randomly divided into control group,hypoxic group and hypoxic+L-arginine group.Pulmonary artery pressure was measured with right cardiac catheterization.Micro-structure and ultra-structure of pulmonary tissue were observed and collagen I expression was evaluated with immunohistochemistry.RESULTS:Mean pulmonary artery pressure(mPAP) was(2.7?0.3)kPa in hypoxic rats and(2.1?0.1)kPa in control rats(P
