Effect of L-menthol on Two Compounds With Different Characteristics in Percutaneously Penetrating Isolated Rabbit Skin
- VernacularTitle:薄荷醇对两种不同性质化合物体外经兔皮吸收的影响
- Author:
Hui WANG
;
Weiming XU
;
Xiaolong FENG
- Publication Type:Journal Article
- Keywords:
l-menthol;
azone;
indomethacinum;
diclofenca sodium;
percutaneous absorption;
deposit effect
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:Indomethacinum(Ind) and diclofenac sodium(Dcs) were taken as model drugs to study the enhancing effect of l-menthol on percutaneous absorption of two compounds with different characteristics,and to probe into the effect of combined use of l-menthol with azone.METHODS:Percutaneous penetration experiment was performed on in vitro device and deposit effect was observed with vivoperception.RESULTS:l-menthol could significantly enhance the percutaneous absorption and shorten the lag times(T1ag) of both Ind and Dcs.The enhancing effects of l-menthol,used either alone or in combination with azone,were several times stronger on Ind than on Dcs.Combined use of two enhances was more effective in enhancing penetration and longer in T1ag than single use of l-menthol,especially for Dcs.The study on deposit effect showed that l-menthol could increase the penetration rate than control agent(P
