Study on Pharmacokinetics of Xuesaitong Injection
- VernacularTitle:血塞通注射液药代动力学研究
- Author:
Yanping WANG
;
Qingbiao MENG
;
Weidong WANG
;
Peihai SHI
- Publication Type:Journal Article
- Keywords:
Xuesaitong injection;
pharmacokinetics;
ginsenoside Rg1;
HPLC
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine the pharmacokinetic parameters of Xuesaitong injection in rabbits.METHODS:Using ginsenoside Rg1 in Xuesaitong injection as a marker,the determination was carried out with HPLC.The detection conditions were:mobile phase,acetonitrile-water(3∶7);chromatgraph column,Hypersil C18(250mm?4.6mm,5?m);detection wavelength,210nm and flow rate,1 ml/min.RESULTS:After intravenous injection,the plasma concentration time data was found to be in accordance with the 2-compartment model in rabbits.The pharmacokinetic parameters were obtained with PKBP-NI.CONCLUSION:The method is simple,accurate and reliable.It could be used to determine the concentration of ginsenoside Rg1 in plasma.
