Preparation of a Newly-developed Contrast Medium for Echocardiography:Air-albumin Microsphere
- VernacularTitle:新型左心声学超声造影剂空气白蛋白微球制剂的研制
- Author:
Youliang SHAN
;
Lianbing HOU
;
Zhiliang CHEN
;
Shiting LIU
;
Yili LIU
- Publication Type:Journal Article
- Keywords:
contrast agent for ultrasonic visualization;
orthogonal design;
human albumin microsphere
- From:
China Pharmacy
1991;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preparation of 5% albumin microspheres by sonication and the possible mechanism of microsphere forming.METHODS:The preparation technic was optimized with orthogonal design.The microsphere diameter was measured with Coulter multisizer and the outward apperance was observed with light and electronic microscope.RESUL_TS:The optimal preparation technic was as follows:5% albumin in NS,ultrasound power at 9th grade and 60 seconds of sonication.CONCLUSION:The albumin microspheres filled with air can be successfully prepared with orthogonal design and can be effectively used in intravenous myocardial contrast echocardiography.
