The Study on the Activity of Protein Kinase C in Platelets of Maternal Vein and Umbilical Blood in Pregnancy Induced Hypertension Syndrome Patients
- VernacularTitle:妊娠高血压综合征患者外周血与脐血血小板蛋白激酶C活性变化的研究
- Author:
Tao SHANG
;
Chong QIAO
;
Xin YU
- Publication Type:Journal Article
- Keywords:
Pregnancy complications, cardiovascular;
Hypertension;
Protein kinase C;
Fetal, growth retardation;
Blood platelets
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship among the activity of protein kinase C (PKC) in platelets of maternal vein and umbilical blood , the pathophysiological changes of pregnancy induced hypertension (PIH) and fetal growth restriction (FGR) in PIH patients. Methods Activities of PKC in membrane and plasma of platelets from maternal vein and umbilical blood taken from 35 PIH patients and 20 normal pregnant women were measured with substrate phosphorylation method. Results No difference was shown in the PKC activities between the mild PIH patients and normal pregnant women in both maternal and cord blood.The PKC activities in moderate and severe PIH patients were significantly higher than those of the normal pregnant group.In normal pregnant women, the PKC activity in membrane and plasm of the platelets had no significant difference. In the moderate and severe PIH group, PKC activity in membrane was far more higher than the plasm 46?6 vs 37?4 pmol/(min?mg protein), P
