The Role of Cytokines in the Pathogenesis of Pregnancy Induced Hypertension
- VernacularTitle:免疫细胞因子在妊娠高血压综合征发病中的作用
- Author:
Yu SUN
;
Shurong ZHENG
;
Shimei ZHOU
- Publication Type:Journal Article
- Keywords:
Cytokines;
Interleukin-1;
Interleukin-4;
Tumor necrosis factor;
Pregnancy complications, cardiovascular;
Hypertension
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the variation of cytokines IL-4, IL-1? and TNF-? before and after the onset of pregnancy induced hypertension (PIH) and to discuss the role of cytokine in the pathogenesis of PIH. Method A prospective cohort study of 550 pregnant women were followed. Plasma drawn from 25 women who developed moderate and severe PIH and 30 controls at 12~16 and 32~36 gestational weeks were analyzed. The concentrations of IL-4, IL-1? and TNF-? were analyzed using ELISA method. Results (1)In the second trimester, the plasma level of TNF-? in PIH group was significantly higher than control group(27.66 ng/L vs 17.80 ng/L, P
