Pharmacokinetics of Metronidazole and Tinidazole in Human Dreast and the Effects on Dreast-fed Infants
- VernacularTitle:甲硝唑、替硝唑在乳汁中的含量及其对母乳喂养新生儿的影响
- Author:
Yinmei DAI
;
Hong ZHANG
;
Xiuhua WANG
- Publication Type:Journal Article
- Keywords:
Metronidazole;
Tinidazole;
Milk, human;
Breast feeding;
Infant, newborn
- From:
Chinese Journal of Perinatal Medicine
1998;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of metronidazole and tinidaxole in breast milk on infants and their concentrations. Methods The concentration of metronidazole and tinidazole inbreast milk was assayed by high performance liquid chromatography(HPLC). Results The pharmacokineticparameters(mean?s) t max(h), t 1/2ke of Metronidazole(20 mg/kg, n=8 ) and Tinidazole (13 mg/kg,n=7) in lactation women infused with a single dose were(1.7?1.0)h、(20?5) mg/L and (1.3?0.6)h、(17?3) mg/L respectively. The total amount of metronidazole and tinidazole ingested by the infant via breast milk were 3.02 mg/kg/day and 2.58 mg/(kg?d) respectively. which were 1/5~1/10. and 1/6~1/8 of the routine therapeutic dose for infants.
