The expression of the growth factors and the receptors related to angiogenesis in intraocular tissues incarcerating in sclerotomy sites
- VernacularTitle:与血管生成相关的生长因子及其受体在巩膜穿刺孔嵌顿组织内的表达
- Author:
Wen LIU
;
Shibo TANG
;
Suying HUANG
- Publication Type:Journal Article
- Keywords:
Vitrectomy;
Neovascularization,pathologic;
Postoptrative complications;
Growth substances/analysis
- From:
Chinese Journal of Ocular Fundus Diseases
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression of the growth factors and the receptors related to angiogenesis in the intraocular tissues incarcerating in the sclerotomy sites. Methods Ten specimens from prolapsing intraocular tissues in sclerotomy sites during vitrectomy were obtained and serially sectioned in cryostate and were stained with a group of polyclonal antibodies against vascular endothelial growth factor(VEGF), basic fibroblast growth factor (bFGF), platelet derived growth factor A(PDGF A) and transforming growth factor ? 1(TGF ? 1) as well as their receptors by using a streptavidin peroxidase system. Results The tissues prolapsed from the sclerotomy sites were identified as retina(3 cases), vitreous tissues(3 cases), degenerated red blood cell components(2 cases), ciliary body(one case) and fibrous tissue(one case). All specimens expressed VEGF and bFGF as well as their receptors. PDGF A, TGF ?1 and their receptors expressed in the most of specimens. The positive cells included retinal cells, ciliary non pigmented epithelial cells and pigmented epithelial cells, fibrous cells and the cells in vitreous. Conclusions The intraocular tissues incarcerated in the sclerotomy entries express the growth factors and receptors related to angiogenesis. This might be one of the potential factors of developing anterior proliferative vitreoretinopathy.
