Changes of Serum Endotoximia and Interleukin-6 Levels Before and After Treatment at Intestine Depollution and Adjustment Intestine Microenvironment in Patients With Liver Cirrhosis
- VernacularTitle:肝硬化患者肠道去污、调整肠道微环境治疗前后血清内毒素及IL-6水平的变化
- Author:
Yanjun CHU
;
Yanru LU
;
Changqing GUO
- Publication Type:Journal Article
- Keywords:
Cirrhosis;
Interleukin-6;
Endotoxemia;
Ascites;
Spontaneous Bacterial Peritonitis(SBP)
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of serum endotoxin and interleukin-6 level before and after treatment at intestine get rid of filth and adjustment intestine microenviroment in patients with advanced stage liver cirrhosis and to oberserve the incidence of spontaneous bacterial peritonitis(SBP) and to research a method that can more efficient reduce the incidence of SBP.Methods Group A was given conventional treatment such as protection liver,supplement human albumin and uragogue;goup B was given FPA 0 2g tid po,continuous three days on the basis of two weeks conventional treatment,group C was given Tab comfort get 0 5g tid po,Changtai orally taken liquid,10ml tid po,lactulose 10ml tid po, for all 8 weeks,on the basis of group B treatment after pausing use FPA.Results Serum endotoxin and interleukin-6 levels in group A was not significantly changes after treatment,,SBP incidence was higher than both group B and group C;at group B,serum endotoxin and interleukin-6 levels decline,SBP incidence significantly drop afer treatment,at group C,serum endotoxin,interleukin-6 level and SBP incidence significantly drop,the difference was significant at statistics as compared with group A and B.Conclusions The treatment at intestine get rid of filth and adjustment intestine microenviroment can effectively reduce serum endotoxin and interleukin-6 levels and can significantly reduce the incidence of SBP.
