The Effects of Mutant p53 Protein Expression on the Pre-operationPatients with Breast Carcinoma Treated with Adriamycin Chemotherapy
- VernacularTitle:变异型p53蛋白表达对乳腺癌手术前阿霉素化疗疗效的影响
- Author:
Ailan CHENG
;
Jianguo CAO
;
Zhaoyang LUO
- Publication Type:Journal Article
- Keywords:
Breast,cancer;
Chemotherapy;
Adriamycin;
p53 expression;
Resistance
- From:
Journal of Chinese Physician
2001;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influences of mutant p53 protein expression on the resistance of breast cancer cells to adriamycin and efficiency of adriamycin chemotherapy of the pre-operative patients with breast carcinoma.Methods Mutant p53 protein expression in 9 cases of breast cancer was examined by using inmunohistochemical method and image semiquantified analysis.The response of human breast cancer cells to adriamycin was tested with MTT assay in order to judge the effects of mutant p53 protein expression on the pre-operative pateints with breast carcinoma treated with adriamycin chemotherapy.Results ⑴Mutant p53 protein expression in 7 cases of the human breast cancer samples were positive,the positive rate was 77%(7/9).⑵There was positive relationship between expression degree of mutant p53 protein(positive relative area) and resistance index(IC50:1/10 peak concentration) of human breast cancer cells to adriamycin(r=0 7956,P
