Influence of L-form infection on tumor necrosis factor and platelet-derived growth factor levels in gallbladder mucosa
- VernacularTitle:L型细菌感染对胆囊黏膜肿瘤坏死因子和血小板源生长因子水平的影响
- Author:
Xingyuan JIAO
;
Jiefu HUANG
;
Mingde LU
;
Lijian LIANG
- Publication Type:Journal Article
- Keywords:
TUMOR NECROSIS FACTOR/blood;
PLATELET-DERIVED GROWTH FACTOR/blood;
GALLBLADDER NEOPLASMS/blood;
L-FORMS;
GALLBLADDER NEOPLASMS/etiol
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of tumor necrosis factor-?(TNF-?) and platelet-derived growth factor(PDGF) in gallbladder carcinoma (GA) patients with cell wall-deficient bacleria(L-form) infection .Methods The levels of TNF-? in gallbladder mucosa were detected by radioimmunoassay and the activity of PDGF was detected by bioactivity assay in patients with GA or cholecystitis and normal gallbladder(control group).Results The positive detection rates of L-forms in gallbladder mucosa of gallbladder carcinoma , chronic cholecystitis, and control group were 80.0%(16/20),82.5%(33/40) and 0(0/20), respectively.The TNF-? and PDGF levels in patients with L-form infection-positive gallbladder carcinoma were significantly higher than those in patients without L-form infection and in control group.The levels of TNF-a and PDGF in patients with L-form infection positive chronic cholecystitis were significantly higher than those in patients without L-form infection and in control group.Conclusions L-form may be one of the direct factors leading to the increase in PDGF during gallbladder oncogenesis,and there is positive correlation between PDGF and gallbladder oncogenesis when L-form induces inflammatory reaction and predisposes gallbladder mucosa to develope neoplasms.
