Effects of sterigmatocystin on interferon-? secretion of human peripheral blood mononuclear cells in vitro
- VernacularTitle:杂色曲霉素对体外培养HPBMcIFN-?分泌的影响
- Author:
Xianghua HUANG
;
Xianghong ZHANG
;
Xia YAN
;
Guiran YIN
;
Yuehong LI
;
Yanwei TAN
;
Junling WANG
;
Fengron WANG
- Publication Type:Journal Article
- Keywords:
Sterigmatocystin;
Monocytes;
Human;
Lymphocytes;
Interferon typeⅡ
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the putative effects of sterigmatocystin (ST) on human help T lymphocyte(Th1)function. METHODS: The effects of ST on interferon-?(IFN-?)secretion of human peripheral blood mononuclear cells(HPBMc) in vitro were determined with ELISA method. RESULTS: The effects of ST on IFN-? secretion of HPBMc in vitro were closely dependent on ST concentrations. ST at relatively lower concentrations (0.03125-0.12500 mg/L) showed inhibiting effects on IFN-? secretion. While, stimulating effects could be found when ST concentration was above 0.25mg/L. The highest level was seen in ST 1 mg/L group ( P
