Progress in the research of mechanism underlying the inhibitory effect of thrombospondin-1 on tumor angiogenesis
- VernacularTitle:血小板反应素-1抑制肿瘤血管生成机制的研究进展
- Author:
Jin XU
;
Xulong ZHOU
- Publication Type:Journal Article
- Keywords:
Thrombospondin 1;
Neovascularization, pathologic;
Neoplasms
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Inhibition of tumor neovascularization (angiogenesis) has become one of the novel therapeutic strategies for tumor, and natural inhibitor of angiogenesis has been highlighted in this field. Thrombospondin-1 (TSP-1), as an important extracellular matrix component which can influence endothelial cell adhesion, migration, and proliferation, is reported to be a potent inhibitor of angiogenesis in vivo. It will be valuable to use its active peptides or small fragments from TSP-1 in antiangiogenesis therapy.
