mRNA Expression of Caspase-1 and Caspase-3 in the Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus Erythematosus
- VernacularTitle:系统性红斑狼疮患者外周血单一核细胞Caspase-1和Caspase-3mRNA的表达
- Author:
Juanqin GONG
;
Zhiqiang CHEN
;
Zijia HU
;
Wengzhong LI
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Caspase 1;
Caspase 3;
Apoptosis
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mRNA espression level of Caspase-1 and Caspase-3 in the patients with systemic lupus erythematosus(SLE) and its association with lymphocyte apoptosis. Methods Reverse transcription-polymerase reaction (RT-PCR) technique was applied to semiquantitatively analyze the mRNA expression of Caspase-1 and Caspase-3 in the peripheral blood mononuclear cells (PBMC) from 34 active SLE patients and 30 healthy subjects. Results Compared with normal controls, the mean levels of Caspase-1 or Caspase-3 mRNA expression in active SLE group was significantly increased(P0.05). Conclusion There are increased expressin of Caspase-1 and Caspase-3 in the PBMC of SLE patients, which may be involved in the lymphocyte apoptosis of SLE patients.
