The mRNA Expression of Transforming Growth Factor-?1 and ?2 in Lesions of Scleroderma
- VernacularTitle:硬皮病患者皮损转化生长因子?1、?2mRNA的表达
- Author:
Kemin SONG
;
Tong LIU
;
Peihua QU
;
Youming SU
;
Rongya YANG
- Publication Type:Journal Article
- Keywords:
Scleroderma;
Transforming growth factor beta
- From:
Chinese Journal of Dermatology
1995;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of transforming growth factors(TGF-?1 and ?2) in the pathogenesis of scleroderma(SD). Methods The mRNA expression of TGF-?1 and ?2 in the skin lesions from 17 patients with SD and skin from 10 normal controls were detected with in situ RT-PCR technique. Results A higher positive rate and stronger expression of TGF-?1 mRNA in SD skin lesions were seen, compared with those in controls(P0.05).The higher positive rate and stronger expression of TGF-?1 mRNA than TGF-?2 mRNA in SD were seen(P
