The pathological change in transitional mucosa adjacent to the rectal cancer and its clinical significance
- VernacularTitle:直肠癌旁移行粘膜病理变化的动态观察与临床意义
- Author:
Pan CHI
;
Tianming HU
;
Daliang CHEN
- Publication Type:Journal Article
- Keywords:
Rectal neoplasms;
Mucosa membrane;
Neoplasm recurrence, local
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the biopathologic characteristics of transitional mucosa (TM) adjacent to rectal cancer and its relationship to the anastomotic recurrence after curative surgery of rectal cancer. Method The expression of p53,p21 ras and PCNA proteins was determined immunohistochemically in primary rectal adenocarcinomas (n=67), the proximal margins (n=67), the distal margins (n=67) and rectal mucosa 1～3?cm distant to the anastomosis in patients one year after radical resection (n=33), and two years after (n=31).Results The expression of TM, p21 ras and p53 proteins,and PCNA index in primary rectal adenocarcinomas was higher than that in two resection margins (P0.05). Positive TM was often found in the area of chronic inflammation. conclusion TM adjacent to the rectal cancer is a nonspecific, not cancer precursor event.
