The cytotoxicity of IL-1? on primary cultured rat hepatocytes
- VernacularTitle:白细胞介素-1?对原代培养大鼠肝细胞的细胞毒性作用
- Author:
Zhongtao ZHANG
;
Yu WANG
- Publication Type:Journal Article
- Keywords:
Hepatocyte;
Interleukin-1;
Cytotoxicity, immunologic;
Cell division;
Metabolism
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effect of IL-1? on primary cultured rat hepatocytes (PCRH).MethodsUsing PCRH of Wistar rats, the cytotoxicity of IL-1? (LDH release), the influence of IL-1? on cell proliferation and cellular energy metabolism (intracellular ATP content and KBR) were observed.ResultsIL-1? significantly increased LDH release on all 6 culture conditions with LDH activities of 22?2,25?4,18?5,12?4,15?5 and 11?4, in individual controls compared with 36?3,43?5,34?6,31?4,31?5 and 22?3,in individual IL-1? treated groups, all P
