Effects of rhGH on the expression of growth hormone receptor of liver cells in a murine experimental cirrhosis model
- VernacularTitle:重组生长激素对实验性肝硬化肝细胞生长激素受体表达的调控作用
- Author:
Hongtao WANG
;
Meihai DENG
;
Qingjia OU
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis,experimental;
Somatotropin;
Receptors, somatotropin
- From:
Chinese Journal of General Surgery
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study growth hormone activated regulation of growth hormone receptors (GHR) in cirrhotic hepatocytes. MethodsPrimary cultures of hepatocytes from cirrhotic rat were exposed to recombinant human growth hormone (rhGH) at different concentrations of 0, 13.3, 133.3,and 1?333?ng/ml, respectively. Thereafter the binding sites of hepatocytes were detected with radio-ligand binding assay. ResultsAfter culture with different rhGH concentrations, the binding sites (10 4/cell) of receptors on cirrhotic liver cells were respectively 0.73?0.13, 1.14?0.17, 1.23?0.21, and 0.68?0.10(P
