Changes of IL-18 and sFas/sFasL in Sera From Patients with SLE
- VernacularTitle:SLE患者血清中IL-18和sFas及sFasL的变化
- Author:
Xiangxiong ZHENG
;
Ping LI
;
Shiwen ZOU
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
IL-18;
Soluble Fas;
Soluble FasL
- From:
Journal of Chinese Physician
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between IL-18 and apoptosis in patients with SLE by using testing the changes of IL-18 and soluble Fas/soluble Fas ligand in sera from the patients.Methods 58 patients with SLE were divided into three groups according to their SLEDAI score;sera from 58 patients,and 30 normal controls were tested for IL-18 and sFas/sFasL using ELISA assay.Results The level of IL-18 and sFas in sera from SLE patients was significantly higher than that of normal controls(P0 05).Besides,the increased level of IL-18 was correlated well with the increased level of sFas (?=0 496,P0 5).Conclusion The increased level of IL-18 may result in the elevation of serum sFas/sFasL in patients with SLE.They may play important roles in the pathogenesis of SLE.
