Clinical significance of perioperative alternations of platelet, coagulation,and fibrinolysis in patients with portal hypertension
- VernacularTitle:门静脉高压症患者围手术期血小板、凝血和纤溶变化的临床意义
- Author:
Zhongmin DI
;
Weiyao CAI
;
Hongwei LI
;
Weiping YANG
;
Guangwen ZHOU
- Publication Type:Journal Article
- Keywords:
HYPERTENSOIN,PORTAL/blood;
HYPERTENSION,PORTAL/surg;
PLATELET COUNT;
BLOOD COAGULATION TESTS
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance of platelet, coagulation ,and fibrinolysis alteration in perioperative period in patients with different Child classifications of cirrhosis. Methods Alterations on the platelet count and the indices of coagulation and fibrinolysis in 17 cases of Child B class who underwent portal-systemic shunt, and 6 cases of Child C class who underwent portal-azygus vein disconnection were detected. Results Before operation,except the decrease in platelet count, there as no significant difference in the indices of other platelet function, coagulation and fibrinolysis in patients with Child B class compared with control group. While in patients with Child C class, the platelet count decreased, and GMP-140, FPA and D-dimer increased greatly. After operation, GMP-140 increased in patients with Child B class, while decreased in patients with child C class. The platelet count and factorⅧ:C in patients with Child C class decreased significantly compared with those with Child B class. Conclusions Operation may induce DIC in patients with Child C class, so it is necessary to determine the fibrinogen and factorⅧ:C during the operation.
