Splenic macrophage in the occurrence of hypersplenism in patients with portal hypertension
- VernacularTitle:脾脏巨噬细胞在门静脉高压症脾功能亢进发生中的作用
- Author:
Yongxiang WANG
;
Guowei LI
;
Zongfang LI
- Publication Type:Journal Article
- Keywords:
HYPERTENSION, PORTAL/blood;
HYPERSPLENISM/blood;
MACROPHAGE;
SPLEEN/pathol
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of splenic macrophage(M) in the occurrence of hypersplenism in patients with portal hypertension(PHT). Methods The changes in the quantity, distribution, ultrastructure of M, the quantity acid phophatase in M ,and the quantity of M phagocytizing blood cells were determined by immunohistochemistry and transmission electron microscopy in the normal and PHT spleen. Results Compared with normal spleen, the cell density of the M in PHT spleen decreased;and the quantity of acid phophatase in M increased; the surface folopodia of M increased and lengthened;and the quantity of lysosome in M and the quantity of M phagocytizing blood cells increased. Conclusions The splenic M may play an important role in the occurrence of hypersplenism in PHT.
