Protective effect of ischemic preconditioning on liver ischemia/reperfusion injury in rats with cirrhosis
- VernacularTitle:缺血预处理对肝硬化大鼠肝缺血再灌注损伤的保护作用
- Author:
Wenmei LI
;
Jian CHEN
;
Kuiyang LU
;
Sigang SHEN
- Publication Type:Journal Article
- Keywords:
REPERFUSION INJURY/prev;
LIVER/blood supply;
LIVER CIRRHOSIS/physiopathol;
ISCHEMIC PRECONDITION
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of ischemic preconditioning(IP) on liver ischemia/reperfusion(I/R)injury in rats with cirrhosis.Methods Thirty-two SD rats with liver cirrhosis induced by carbon tetrachloride were randomly divided into IP group and Non-IP(NIP) group,according to whether an IP was performed before liver I/R injury or not.The function of liver, superoxide dismutase(SOD),glutathione peroxidase(GSH-PX),malonyldialdehyde(MDA),adenine nucleotide(ATP,ADP,AMP),energy charge(EC),nitric oxide(NO)in liver tissues,the changes in liver histology,and one-week survival rate after the test in both groups were compared.Results Compared with NIP group,the serum AST,ALT ,and LDH and the MDA contents significantly decreased(P
