Effect of hepatocyte growth factor on hepatocytes after partial hepatectomy in cirrhotic rats
- VernacularTitle:促肝细胞生长素对慢性肝损伤鼠肝部分切除术后肝细胞的影响
- Author:
Hong ZHU
;
Yongzhang GUO
;
Li LI
;
Jie ZHANG
;
Zhibin YAN
- Publication Type:Journal Article
- Keywords:
HEPATOCYTE GROWTH FACTOR/pharmaco;
LIVER/drug eff;
LIVER/physiol;
HEPATECTOMY;
REGENERATION
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of hepatocyte growth factor (HGF) on hepatocytes after partial hepatectomy in chronic liver injury rats.Methods 30% hepatectomy was performed in rats with cirrhosis induced by CCL 4 and alcohol,and subcutaneously injection of cow HGF into intraabdomen was done with different dosages.Results Small dose (0.16mg?100g -1d -1)of HGF did not stimulate liver regeneration or enhance liver function after partial hepatectomy in cirrhotic rats.Large dose (1.3mg?100g -1d -1) of HGF stimulated liver regeneration and enhanced liver function after partial hepatectomy in cirrhotic rats(P
