Apoptosis in the acute rejection of Hamster-to-Rat liver transplantation
- VernacularTitle:异种肝移植急性排斥反应中细胞凋亡的研究
- Author:
Jingwang TAN
;
Shaogeng ZHANG
;
Yi JIANG
;
Jiamei YAN
;
Guangxiang QIANG
;
Menchao WU
- Publication Type:Journal Article
- Keywords:
LIVER TRANSPLANTATION/immunol;
GRAFT REJECTION;
APOPTOSIS;
TRANSPLANTATION,HETEROLOGOUS
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the occurrence of apoptosis in acute rejection of hamster-to-rat liver transplantation and the molecular mechanism. Methods On the basis of establishment of hamster-to-rat orthotopic liver transplantation, the apoptosis in xenograft were observed by histology and in situ end-lebelling of fragmented DNA;the expression of Fas-L and TGF-?1 were observed by Immunohistochemistry. Rseults In acute rejection of liver xenograft, the apoptosis of hepatocyte was detectable, meanwhile, the expression of Fas-L and TGF-?1 were found. The more severe apoptosis, the more severe acute rejection , and the more expression of Fas-L and TGF-?1 . Conclusions Apoptosis as a mechanism of cell death exists in the acute rejection of liver xenograft, and it is closely related to the expression of TGF-?1 and Fas-L.
