Granulocyte colony-stimulating factor mobilized bone marrow stem cells treat the acute myocardial infarction
- VernacularTitle:粒细胞集落刺激因子动员骨髓干细胞治疗大鼠急性心肌梗塞
- Author:
Yunxian CHEN
;
Ruiming OU
;
Xueyun ZHONG
;
Liye ZHONG
;
Huizhen CHEN
;
Longyun PENG
;
Wutao ZENG
;
Sanqing JIN
;
Xi ZHANG
;
Zhongcha HAN
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Bone marrow;
Stem cells;
Granulocyte colony-stimulating factor;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of granulocyte colony-stimulating factor (G-CSF)-mobilized bone marrow stem cells on treatment of the myocardial infarction in experimental rats. METHODS: Three hours after injected with isoprenaline(ISO) interaperitoneally to develop acute ischemic model, rats' bone marrow stem cells were mobilized by G-CSF and migrated to the site of myocardial infarction. The hearts were harvested from 24 hours to 2 weeks after administration of ISO for histopathological examination. RESULTS: 24 hours after administration of ISO , myocardial infarct zones scattered in the pallium of the control group ,there were a large amoumt of inflammatory cells infiltration around the infarct zones and majority of them were neutrophils. The infarction in the G-CSF treatment group was milder, majority of the infiltrative cells were monocytoid; 48 hours after administration of ISO, infarct zones expanded greatly in control group, while that of the G-CSF treatment group increased just mildly; 2 weeks after administration of ISO, there was no significant scar in the G-CSF treatment group. We also found the regeneration of myocytes in the pallium. CONCLUSION: G-CSF treatment protected the ischemic myocardium and it may be used to treat the acute myocardial infarction.
