Effect of G?q/11-mediated signal transduction pathway in cardiac hypertrophy induced by angiotensin II
- VernacularTitle:G?q/11信号转导通路在血管紧张素Ⅱ引起心肌肥大中的作用
- Author:
Hua BAI
;
Dongqi XING
;
Yinping SUN
;
Lilin WU
- Publication Type:Journal Article
- Keywords:
Hypertension,renal;
Hypertrophy;
Myocardium;
Angiotensin Ⅱ
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the role of G?q/11-mediated signal transduction pathway in cardiac hypertrophy induced by angiotensin II (AngII). METHODS: Renal hypertension was performed by placing a sliver clip around the left renal artery(2K1C). Hemodynamic parameters, the ratio of left ventricular weight to body weight, the AngII contents and the activities of phospholipase C (PLC) in myocardium were measured at 1st, 2nd, 4th and 8th week after operation, respectively. The levels of G?q/11 were assayed by Western blot analysis. -leucine incorporation and levels of G?q/11 were measured in cultured neonatal rats ventricular myocyte after AngII stimulation. RESULTS: In 2K1C group, blood pressure and the ratio of left ventricle of heart to body weight were significantly increased compared with sham group between 2nd to 8th week. AngII content increased from 1st to 8th week after operation. Compared with the sham group, levels of G?q/11 in 2K1C group increased by 25.0% and 35.8% at 4th and 8th week( P
