Effect of HOE642 on myocardial ischemia/reperfusion injury and apoptosis
- VernacularTitle:HOE642对心肌缺血再灌注损伤及细胞凋亡的影响
- Author:
Yun ZHANG
;
Furong ZHANG
;
Junzhu CHEN
;
Qian XIA
- Publication Type:Journal Article
- Keywords:
Sodium-hydrogen antiporter;
Myocardial reperfusion injury;
Apoptosis;
Ischemia
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To clarify the effect of the specific sodium-hydrogen antiporter HOE642 on ischemia/reperfusion(I/R) injury including apoptosis, and the relationship between its effect and the time of HOE642 administration. METHODS: The isolated rat heart model were randomly divided into group A and B. Furthermore, the rat hearts in group A were divided into four subgroups including I/R, HOE-Pr+I/R, HOE-Is+I/R and HOE-Re, also the rat hearts in group B were divided into the following subgroups including control, I/R and HOE642+I/R. The LVDP, LVEDP, arrythmia coronary flow and the enzymatic activity in myocardium were measured in group A, and TUNEL method was applied to probe apoptosis in group B. RESLUTS: It was found that the LVEDP, arrythmias and the enzymatic activity including CK-MB and LDH were significantly lower in group HOE-Pr+I/R than that in group I/R, while the LVDP was obviously higher in HOE-Pr+I/R than that in I/R. The administration of HOE642 during ischemia could decrease LVEDP, arrythmias and enzymatic activity in myocardium, but not the LVDP. Furthermore, the results showed that HOE642 could inhibit apoptosis induced by ischemic/reperfusion injury. CONCLUSIONS: HOE642 is an effective cardio-protector in case of ischemic/reperfusion injury especially when it is applied before ischemia. The inhibition of apoptosis might be involved in the mechanisms underlying the protective effect of HOE642.
