Urinary Transforming Growth Factor-beta1 (TGF-beta1)/Creatinine Ratio and Its Clinical Implications in Childhood Acute Pyelonephritis.
- Author:
Hyewon HAHN
1
;
Jun Ho LEE
;
Eun Young UM
;
Il Soo HA
;
Hae Il CHEONG
;
Yong CHOI
Author Information
1. Department of Pediatrics, College of Medicine, Ulsan University, Asan Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Acute pyelonephritis;
Children;
Urinary transforming growth factor- beta1;
Renal scar
- MeSH:
Child;
Cicatrix;
Creatinine;
Enzyme-Linked Immunosorbent Assay;
Humans;
Infant, Newborn;
Kidney Failure, Chronic;
Pyelonephritis*;
Pyuria;
Transforming Growth Factor beta1;
Urinalysis
- From:Korean Journal of Nephrology
2003;22(5):546-551
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Pyelonephritis is one of the major causes of chronic renal failure in children, and the transforming growth factor-beta1 (TGF-beta1) is a molecule with pivotal roles in fibrogenesis. This study was performed to investigate the alteration and clinical implications of urinary TGF-beta1/creatinine ratio in children with acute pyelonephritis. METHODS: Urine was collected from 67 normal children and 25 children with acute pyelonephritis. After routine urinalysis, urine TGF-beta1 was quantitated by ELISA method and creatinine was measured by alkaline picrate method. Urinary TGF-beta1/ creatinine ratios in children with pyelonephritis were compared with those of age-matched controls, and sequential changes of the ratios in pyelonephritic children were traced after antibiotic treatment. Correlation of urinary TGF-beta1/creatinine ratio with the degree of pyuria and renal scar was analyzed each. RESULTS: Neonates showed higher urinary TGF-beta1/creatinine ratios than older children. The ratio increased in acute pyelonephritis and gradually returned to the control level two days after antibiotic treatment. Urinary TGF-beta1/creatinine ratio in acute pyelonephritis was not correlated with the degree of pyuria and renal scar. CONCLUSION: The age should be considered in evaluation of urinary TGF-beta1/creatinine ratio in children. The ratio increases in acute pyelonephritis, and is independent of the degree of pyuria or renal scarring.
