Effects of rat tail collagen and C-erbB-2 antibody on the adhesion and proliferation in hepatocellular carcinoma cell
- VernacularTitle:鼠尾胶原及C-erbB-2蛋白抗体对肝癌(HepG-2)细胞粘连和增殖的影响
- Author:
Haiwei ZHANG
;
Yingru LUO
;
Xiaolin CHEN
;
Peie ZHENG
;
Ru SITU
- Publication Type:Journal Article
- Keywords:
Hepatoma;
Adhesions;
Antibodies;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of collagen and C-erbB-2 protein on the adhesion and the proliferation in hepatocellular carcinoma cells.METHODS: Hepatocellular carcinoma cell line(HepG-2) identified to positive for C-erbB-2 gene was used to study the adhesion and the growth feature by the action of rat tail collagen and C-erbB-2 antibody.RESULTS: The action of rat tail collagen to potentiated the adhesion in HepG-2 cells was significantly but no proliferation effect was observed. C-erbB-2 antibody inhibited the adhesion and proliferation of HepG-2 cells and also abolished the potentiated effect of rat tail collagen on the adhesion in HepG-2 cells.CONCLUSIONS: The signaling transduction mediated by C-erbB-2 protein was correlated to the adhesion and the proliferation of HepG-2. The blockage of C-erbB-2 gene signal transduction may be a strategic target to the treatment of liver cancer in the future.
