Effect of ?-amyloid protein on the fluidity of mitochondrial membrane in hippocampus of aging rats induced by D-galactose
- VernacularTitle:?-淀粉样蛋白对D-半乳糖致衰大鼠海马线粒体膜流动性的影响
- Author:
Ya LI
;
Jianjun WANG
;
Qishen CHEN
- Publication Type:Journal Article
- Keywords:
Amyloid beta-protein;
Aging;
Alzheimer's disease;
Membrane fluidity;
Na(+)-K(+)-exchanging ATPase
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of ?-amyloid protein (?-AP) on the fluidity of mitochondrial membrance in hippocampus of the aging model of rats.METHODS: Based upon the model of aging rats induced by D-galactose (D-gal) and hippocampal microinfusion of ?-AP, the behaviors of rats were observed. Using DPH as fluorescent probe, the viscous cofficient (?) of mitochondrial membrane was determined, and Na +-K +ATPase activity was measured.RESULTS: In the D-gal+?-AP group rats, Na +-K +ATPase activity was lower than D-gal and ?-AP groups ( P
