Poly(ADP-ribose) polymerase and cell injury
- VernacularTitle:多聚(ADP-核糖)聚合酶与细胞损伤
- Author:
Tienian ZHU
;
Ruijing ZHAO
;
Yilin LING
- Publication Type:Journal Article
- Keywords:
Necrosis;
Apoptosis;
Polynucleotide synthetases
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Poly(ADP-ribose) polymerase(PARP) is a protein-modifying and nucleotide-polymerizing enzyme. As a critical element in DNA repair, PARP can be activated by DNA strand breaks. Excessive activation of PARP, however, can deplete NAD + and ATP, leads to cell death. Cleavage of PARP by activated caspase-3 play an important role in cell apoptosis.
