The protection of spinal cord disfunction caused by acute ischemia
- VernacularTitle:脊髓急性缺血后功能障碍的保护
- Author:
Wei YE
;
Heng GUAN
;
Qi CHEN
- Publication Type:Journal Article
- Keywords:
Postoperative complications;
Spinal cord injuries;
Ischemic preconditioning
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate ischemia preconditioning (IP) and intermittent ischemia (II) in ameliorating the incidence of paraplegia. MethodCross clamping of the infrarenal aorta in New-Zealand rabbit was used to establish a spinal cord ischemia model. 25 rabbits were randomly divided into 3 groups. The continuous ischemia(CS) group (n=10) with the aorta clamped for 40 minutes. While in the IP group (n=6) the aorta was clamped for 3 sessions each lasting for 5 min, with 5 min interval between the sessions before 40 minutes clamping, in the Ⅱ group (n=9) the 40 min clamping was interposed by a 15 min interval. The muscle force of the lower extremity, the excitatory amino acid (EAA) in CSF, the malondiadehyde (MDA)in spinal cord and the pathology were compared between the groups.Result The muscle force of the lower extremity was better in Ⅱ and IP group than that in CS group (3.4?1.0) in Ⅱ, (3.5?0.8) in IP vs (1.3?1.4) in CS, all P
