Immunomodulatory Effects of Theasinesin on Normal and Immunosuppressed Mice
- VernacularTitle:聚酯型儿茶素对小鼠的免疫调节作用
- Author:
Huawen XIN
- Publication Type:Journal Article
- Keywords:
theasinesin;
cyclophosphamide;
immunomodulatory effect;
mouse
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:The effects of theasinesin on the immune functions of normal and immunosuppressed nice were studied.METHODS:The immunosuppressed mice were induced by cyclophosphamide(15mg/(kg?d)?4d,ip).The immunom_odulatory effects of theasinesin were measured by delayed type hypersensitivity(DTH),phagocytosing function assay of peritoneal macrophage,cleaning charcoal particles method,and HC50 method.RESULTS:Theasinesin(50,100,200mg/(kg?d)?7d)could significantly intensify DTH caused by DNFB.It could also improve phagocytosing function of peritoneal macrophage and increase production of serum hemolysins in mice immunized with SRBC.The ear swelling,K,? and the level of serum hem_olysin that were lowered by cyclophosphamide were also markedly increased by theasinesin.CONCLUSION:Theasinesin has an enhanced effect on immunofuctions of normal mice ans immunosuppressed mice.
