Determination of the Contents of Lomefloxacin Hydrochloride in Injection and Capsule With Fluorospectrophotometry
- VernacularTitle:荧光分光光度法测定洛美沙星注射液及胶囊的含量
- Author:
Ruoyan ZHANG
;
Xiaomei OUYANG
- Publication Type:Journal Article
- Keywords:
lomefloxacin hydrochloride;
fluorospectrophotometry;
determination of content
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:A fluorospectrophotometric method was established for the determination of lomefoxacin hydrochloride in injection and capsule.METHODS:Samples were diluted with distilled water and detected by fluorospectrophotometry at excitation wavelength of 285nm and emission wavelength of 445nm.RESULTS:Linear relationship was found in the lomefloxacin hydrochloride concentrations ranging from 0.5?g/ml to 2.5?g/ml.The correlation coefficient was 0.9 998.The recoveries of lomefloxacin in injection and capsule were 99.7%(RSD=0.6%,n=5) and 99.6%(RSD=0.8%,n=5),respectively.CONCLUSION:The method is simple,accurate and sensitive and can be used to determine lomefloxacin hydrochloride in injection and capsule.
