Effects of L-glutamine Granules on Protein Metabolism and Immunofunction in Severely Burned Patients
- VernacularTitle:谷氨酰胺颗粒对严重烧伤患者蛋白代谢和免疫功能的影响
- Author:
Xi PENG
;
Zhongyi YOU
;
Fengjun WANG
;
Pei WANG
;
Yun ZHAO
;
Shiliang WANG
- Publication Type:Journal Article
- Keywords:
glutamine;
protein metabolism;
immunofunction;
burns
- From:
China Pharmacy
1991;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of L-glutamine granules on protein metabolism and immunofunction in severely burned patients.METHODS:39 severe burn patients(total burn surface areas 30%～60%,full thickness burn areas 20%～50%) were randomly divided into two groups:control group(C group,19 patients) and glutamine treatment group(GLN group,20 patients).GLN group patients were given glutamine granules 0.5g/kg daily for 7 days,and C group were given same weight placebo for 7 days.The concentrations of plasma glutamine,prealbumin,transferrin,immunological globulin and IL-2 were determined.Moreover,the wound healing rate of burn area was observed and then hospital stay days were recorded.RESULTS:After 7 days of taking glutamine,the concentrations of plasma glutamine,prealbumin,transferrin IgG,IgM and IL-2 in GLN group were significant higher than those in before medication and C group(P0.05).The wound healing rate was faster and hospital stay days were shorter in GLN group than those in C group(P
