Effects of angiotensin converting enzyme inhibitor on the arterial elastase after balloon injury
- VernacularTitle:血管紧张素转换酶抑制剂对损伤后动脉弹性蛋白酶的影响
- Author:
Qiang SHU
;
Guanglie LING
;
Jia JIANG
- Publication Type:Journal Article
- Keywords:
Pancreatopeptidase;
Arteries;
Muscle, smooth, vascular;
Angiotensin-converting enzyme inhibitors
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effects of angiotensin converting enzyme inhibitor(ACEI) on elastase after balloon injury. METHODS: The carotid arteries and aortas twelve-weeks-old Wistar male rats were injured by balloon catheter. The rats were divided into experimental and control groups in which ACEI (temocapril-HCl,10 mg?kg -1 ?d -1 ) and the vehicle were administered 2 days before injury respectively and the animals were sacrificed on day 2, 3, 5 and 10, respectively. In situ hybridization, immunohistochemistry and elastase activity bioassay were used for studying elastase . RESULTS: The intimal area on day 10 in the experimental group was significantly suppressed compared to that in the control rats( P
