Nitric oxide production, NOS activity and expression in pulmonary arterioles of rats with chronic hypoxic hepercapnic pulmonary hypertension
- VernacularTitle:慢性低O_2高CO_2肺动脉高压大鼠血浆NO和肺动脉NOS及其基因表达的变化
- Author:
Zhengjie XU
;
Liangxing WANG
;
Qunji WANG
;
Hongqi ZHANG
- Publication Type:Journal Article
- Keywords:
Anoxia;
Hypercapnia;
Pulmonary artery;
Nitric-oxide synthase;
Nitric oxide;
Genes
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To clarify the role of nitric oxide (NO) system in development of chronic hypoxic hypercapnic pulmonary hepertension. METHODS: Male Sprague-Dawley rats were randomly divided into control group and hypoxic hypercapnic group. NO content of plasma was determined, constitutive nitric oxide synthase (cNOS) and inducible nitric oxide synthase (iNOS) were examined using the technique of immunohistochemistry, expression of cNOS mRNA and iNOS mRNA of arteriole were detected by in situ hybridization. RESULTS: Plasma NO concentration, cNOS activity and cNOS mRNA expression in arteriole of chronic hypoxic hypecapnic group were significantly lower than that of control group ( P
