Effects of paecilomyces cicadidae total polysaccharides on non-specificity immune regulation in rats
- VernacularTitle:蝉拟青霉总多糖对大鼠非特异性免疫调节作用的研究
- Author:
Liqin JIN
;
Jianxin L
;
Jiezuan YANG
;
Qian YUAN
;
Jing JIN
- Publication Type:Journal Article
- Keywords:
Paecilomyces;
Macrophages;
Immunity;
Rats
- From:
Chinese Journal of Pathophysiology
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the immune regulation of paecilomyces cicadidae total polysaccharides. METHODS: After subcutaneous injection with 200 mg/L paecilomyces cicadidae total polysaccharides in the back of the rats for 17 days, the white blood cell (WBC) counts, and the levels of lipid peroxide (LPO) and reduced glutathione (GSH) in the spleen and thymus of rats were detected. The alveolar macrophages (AM?) cultured with 10% fetal bovine serum-RPMI-1640 for 2 h in vitro , then the activity of lactate dehydrogenase (LDH) and acid phosphatase (ACP) were detected by automatic biochemistry analyzer, and the ability devouring neutral red in the AM? were examined. RESULTS: Compared with control group, the WBC, the levels of GSH in the spleen and thymus, and the activities of LDH and ACP were significantly increased and the ability of devouring neutral red was also strengthened( P
