The prognostic significance of VEGF, p53 and PCNA expression in endoscopic biopsy specimens of patients with early gastric carcinoma
- VernacularTitle:早期胃癌活体组织中血管内皮生长因子、p53蛋白和增殖细胞核抗原表达与预后的关系
- Author:
Jinyu ZHANG
;
Wenzhi QU
;
Jiajun YIN
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Gastroscopy;
Endothelial growth factors;
Protein p53;
Proliferating cell nuclear antigen
- From:
Chinese Journal of General Surgery
2000;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between postoperative tumor recurrence and VEGF expression in preoperative biopsy specimens of early gastric carcinoma together with p53 gene abnormality and tumor cell proliferation. Methods Sixty-eight endoscopically biopsied specimens obtained preoperativelly from patients with early gastric carcinoma were studied immunohistochemically. Date was processed by computer image analysis system. Result The rate of VEGF positivity was significantly higher in patients (n=5) with postoperative tumor recurrence than in those (n=63) without (5/5 vs. 14/63, P
