Study on the Synthetic Technique of Magnesium Gluconate
- VernacularTitle:葡萄糖酸镁合成工艺研究
- Author:
Ji LI
;
Dexian FAN
;
Shujie ZHAO
;
Kejing JIANG
- Publication Type:Journal Article
- Keywords:
magnesium gluconate;
gluconolactone;
magnesium oxide;
orthogonal design;
synthesis
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the synthetic technique of magnesium gluconate METHODS:By taking gluconolactone and magnesium oxide as the semifinished materials,the synthetic technique of magnesium gluconate was optimized by orthogonal design RESULTS:The optimal preparing condition:gluconolactone∶magnesiumoxide(mol∶mol)was 1∶0 6;reaction temperature 100℃;reaction time 3 hours Under the optimal conditions,the drug were synthesized with a rate of total output over 95 0% CONCLUSION:This synthetic technique is stable in output rate,short in reaction period and feasible in operation
